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. 2020 Oct 14;10:17240. doi: 10.1038/s41598-020-73974-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inflammasome and pyroptosis one day after hemorrhagic shock. (a) TLR4 mRNA expression; (b) NLRP3 mRNA expression; (c) Caspase 1 mRNA expression; (d) Western Blot of the cleaved-form of caspase 1; (e) quantification of the expression of cleaved-form of caspase 1 from 4 independent Western-Blots. (f) IL1β mRNA expression. N = 6 per groups for mRNA and n = 4 per group for protein. Sham: non-shocked mice; Ov: ovariectomized mice; Ov + cE2: ovariectomized mice with chronic estradiol substitution; Intact + V: non ovariectomized mice receiving vehicle; Intact + aE2: intact mice receiving 25 µg of estradiol at the end of resuscitation. Relative mRNA expression levels were calculated using the ΔΔCtCt method, normalized to HPRT and β actin, and expressed as fold changes relative to the sham animals. Data are presented as mean ± s.e.m. Data are presented as mean ± s.e.m. *P < 0.01, **P < 0.001 versus sham; ^##P < 0.01 for indicated comparison.