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. 2020 Oct 14;11:5183. doi: 10.1038/s41467-020-18987-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Spectrum of signature 18, with 6 SNV types indicated at top and the trinucleotide context indicated at bottom. C>A mutations commonly affecting driver genes are indicated at bottom. b Heatmap showing probability that each somatic driver SNV (rows) was caused by each signature (columns). Each row represents one mutation in a specific patient. Trinucleotide context of each mutation is indicated at right. Genes are color-coded as indicated in legend at bottom-right. Only driver SNVs in diagnosis WGS samples with highly reliable signature data (cosine reconstruction similarity of 0.9 or higher; n = 38 samples and 42 mutations) were analyzed. Source data are provided as a Source Data file.