Table 2.
Risk factors for liver transplantation (n = 22) versus survival without (n = 75) on day-28
| Characteristics | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
| Odds ratio | p value | Odds ratio | p value | |
| Comorbidity | 0.18 (0.06–0.56) | 0.003 | 0.03 (0.00–0.53) | 0.017 |
| Growth failure | 0.80 (0.26–2.48) | 0.711 | ||
| ACLF | 17.75 (4.79–65.7) | 0.000 | 6.12 (1.06–35.03) | 0.042 |
| Sepsis | 1.58 (0.60–4.12) | 0.344 | ||
| Biliary atresia | 1.79 (0.67–4.12) | 0.241 | ||
| INR ≥ 2.5 | 5.22 (1.88–14.5) | 0.001 | ||
| Bilirubin ≥ 300 μmol/L | 2.88 (1.00–8.30) | 0.050 | ||
| pCLIF-SOFA | 1.21 (1.04–1.40) | 0.011 | 1.3 (1.04–1.67) | 0.019 |
| PELD | 1.06 (1.01–1.11) | 0.009 | ||
Odds ratio are expressed as 95% (confidence interval). On multivariable analysis, centre effect was not significant (p = 0.20)
ACLF acute-on-chronic liver failure, BA biliary atresia, INR International Normalized Ratio, pCLIF-SOFA Paediatric Chronic Liver Failure-Sequential Organ Failure Assessment score, PELD paediatric end-stage liver disease