Table 5.
Risk factors for composite outcome (n = 67) versus survival without liver transplantation (n = 63) on day-60
| Characteristics | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
| Odds ratio | p value | Odds ratio | p value | |
| Comorbidity | 0.31 (0.15–0.64) | 0.002 | 0.16 (0.05–0.52) | 0.003 |
| Growth failure | 1.88 (0.84–4.16) | 0.12 | ||
| ACLF | 5.8 (1.86–18.32) | 0.002 | 2.83 (0.77–11;11) | 0.135 |
| Sepsis | 2.7(1.3–5.62) | 0.005 | 2.1 (0.78–5.58) | 0.137 |
| Biliary atresia | 1.5 (0.76–3.06) | 0.23 | ||
| INR ≥ 2.5 | 3.11 (1.4–6.78) | 0.004 | ||
| Bilirubin ≥ 300 μmol/L | 3.5 (1.54–8.05) | 0.003 | ||
| pCLIF-SOFA | 1.3 (1.18–1.5) | 0.000 | 1.48 (1.25–1.76) | 0.019 |
| PELD | 1.07 (1.03–1.13) | 0.000 | ||
Odds ratio are expressed as 95% (Confidence Interval). On multivariable analysis, centre effect was not significant (p = 0.44)
ACLF acute-on-chronic liver failure, INR International Normalized Ratio, pCLIF-SOFA Paediatric Chronic Liver Failure-Sequential Organ Failure Assessment score, PELD paediatric end-stage liver disease