Table 2.
Univariate and multivariate logistic regression and Cox proportional hazard regression of patient and treatment variables for all patients
| Treatment variable | All n = 2066 median (IQR) | Survivors n = 1794 median (IQR) | Non-survivors n = 272 median (IQR) | Univariate analysis | OR (95% CI) on MVLR | Significance of OR on MVLR | Cox proportional hazard ratio (95%CI) | Significance of Cox proportional hazard ratio |
|---|---|---|---|---|---|---|---|---|
| Time to antibiotics (mins) | 48 (30–82) | 49 (31–83) | 44 (25–77.5) | p = 0.011a | 1.00 (0.99–1.00) | p = 0.89 | 1.00 (0.99–1.00) | p = 0.97 |
| Volume of IVF (ml) | 1000 (1000–2000) | 1000 (1000–2000) | 1000 (1000–2000) | p = 0.1 | 0.99 (0.99–0.99) | p = 0.0001a | 0.99 (0.99–0.99) | p = 0.0006a |
| Final MAP (mmHg) | 83 (74–93) | 84 (75–93) | 81 (69–91) | p < 0.0001 | 1.01 (0.99–1.02) | p = 0.55 | 1.00 (0.99–1.01) | p = 0.62 |
| Urea (mmol/l) | 6.7 (4.6–10.8) | 6.3 (4.4–9.5) | 12.1 (6.9–19.9) | p < 0.0001a | 1.07 (1.05–1.09) | p < 0.0001a | 1.03 (1.02–1.04) | p < 0.0001a |
| Creatinine (micromol/l) | 89 (67–125) | 86 (67–117) | 117 (76–192) | p < 0.0001a | 0.99(0.99–1.00) | p = 0.06 | 0.99(0.99–1.00) | p = 0.51 |
| REDS score | 3 (2–4) | 2 (2–3) | 4 (3–6) | p < 0.0001a | 1.67 (1.55–1.80) | p < 0.0001a | 1.35 (1.27–1.43) | p < 0.0001a |
Hosmer–Lemeshow test for multivariate logistic regression p = 0.28
IVF intravenous fluid, CI confidence interval, MAP mean arterial pressure, REDS score Risk-stratification of Emergency Department suspected Sepsis score, IQR interquartile range, OR Odds Ratio, MVLR multivariate logistic regression
aStatistical significance reached