Table 3.
Univariate and multivariate logistic regression and Cox proportional-hazard regression analyses of patient and treatment variables in patients with refractory hypotension (RH)
| Treatment variable | All n = 117 median (IQR) | Survivors n = 73 median (IQR) | Non-survivors n = 44 median (IQR) | Univariate analysis | OR (95% CI) on MVLR | Significance of OR on MVLR | Cox proportional hazard (95%CI) | Significance of Cox proportional hazard |
|---|---|---|---|---|---|---|---|---|
| Time to antibiotics (mins) | 37 (20–62) | 33 (19–53) | 46 (22.5–78.5) | p = 0.08 | 1.01 (1.001–1.02) | p = 0.03a | 1.01 (1.001–1.012) | p = 0.022a |
| Volume of IVF (ml) | 3000 (2000–3870) | 3000 (2000–3903) | 2800 (2000–3750) | p = 0.26 | 0.99 (0.99–1.00) | p = 0.10 | 0.99 (0.99–1.00) | p = 0.067 |
| Final MAP (mmHg) | 61 (56–68) | 62 (56–71) | 59.5 (55–65) | p = 0.12 | 0.97 (0.93–1.01) | p = 0.14 | 0.99 (0.96–1.02) | p = 0.45 |
| REDS score | 7 (6–9) | 7 (5–8) | 8 (7–10.5) | p = 0.001 | 1.53 (1.23–1.92) | p = 0.0002a | 1.37 (1.17 – 1.60) | p = 0.0001a |
Hosmer–Lemeshow test for multivariate logistic regression p = 0.24
IVF intravenous fluid, CI confidence interval, MAP mean arterial pressure, REDS score Risk-stratification of Emergency Department suspected Sepsis score, IQR interquartile range, OR odds ratio, MVLR multivariate logistic regression
aStatistical significance reached