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. 2020 Oct 14;10:17319. doi: 10.1038/s41598-020-74352-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Co-culture of Human MM in Either Normoxia or Hypoxia Increases Vegf-a Secretion by MLOA5 Osteocytes after 24 h. (a) Murine Vegf-a levels detected by ELISA from varying conditioned media. MM cell lines used: RPMIs, MM1.S, JJN3s. N = 4–6. (b) A similar pattern is seen with 5TGM1 murine MM co-cultures. N = 3–4, (* = p < 0.05, ** = p < 0.01, *** = p < 0.001).