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. 2020 Oct 14;10:17313. doi: 10.1038/s41598-020-73454-w

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© The Author(s) 2020, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pneumolysin is indispensable to the invasive properties of pneumococcal ST615. (A) Upon challenge with ST615 wild-type (WT) or ST615Δply pneumococci, mice were monitored for the development of visual signs of disease (n = 10 mice per group; mean ± SEM). Pain scores were assigned as follows 1: hunched, 2: starry/piloerecti, 3: lethargic, 4: moribund, 5: dead. (B) Kaplan–Meier survival chart monitoring the number of mice succumbing to disease over 3 days upon challenge with ST615 WT versus ST615Δply. (C,D) Pneumococcal viable counts in lung tissues (C, CFU/tissue) or and peripheral blood (D, CFU/ml) upon intranasal infection with ST615ΔPly compared with ST615 WT pneumococci at time of death (TOD). Data are represented as mean ± SEM (n = 10 mice per group). Each mouse is represented by a symbol.