Table 3.
Comparison of patients’ characteristics among the ALI and the SLI groups in patients who progressed to ALF.
| ALI group (n = 5) | SLI group (n = 18) | ||
|---|---|---|---|
| Sex (M: F) | 1: 4 | 12: 6 | n.s |
| Age (range) | 63 (52–85) | 59 (27–82) | n.s |
| Etiology | |||
| AIH, DILI, HBV (acute, carrier, de novo), oral, undetermined | 1: 1: 0: 1: 0: 0: 2 | 3: 2: 3: 4: 2: 1: 3 | n.s |
| Type of disease | |||
| Acute: subacute: LOHF | 1: 3: 1 | 4: 14: 0 | n.s |
| Prognosis (deceased: liver transplantation: survival) | 2: 2: 1 | 12: 6: 0 | n.s |
| Mean (95% CI) | Mean (95% CI) | ||
|---|---|---|---|
| T-Bil (mg/dL) | 17.6 (8.4–26.8) | 13.6 (10.5–16.7) | n.s |
| AST (U/L) | 407 (139–676) | 1703 (785–2622) | n.s |
| ALT (U/L) | 524 (174–873) | 2188 ( 1077–3298) | p = 0.0188 |
| Cre (mg/dL) | 0.98 (0.06–2.04) | 1.15 ( 1.66–0.67) | n.s |
| PT-INR | 1.58 ( 1.50–1.67) | 3.36 (2.59–4.13) | p = 0.0046 |
Wilcoxon/Kruskal–Wallis test was performed for comparison among continuous values. AIH autoimmune hepatitis, ALT alanine aminotransferase, AST aspartate aminotransferase, Cre creatinine, DILI drug‐induced liver injury, HBV hepatitis B virus, LOHF late-onset liver failure, Oral hepatitis due to oral infection, PT-INR prothrombin time international normalized ratio, SLI severe acute liver injury, T-Bil total bilirubin.