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. 2020 Oct 14;10:17295. doi: 10.1038/s41598-020-74230-6

Figure 5.

Figure 5

Effects of one injection of BUP-Depot compared to two injections of non-retard formulation after sham-ovariectomy on nest complexity score, body weight, food and water intake. (a) Nest scores during baseline measurements on day 1 and 2 and 24 h post-surgery show no significant differences between both groups at any time point (Day 1: P = 0.92; Day 2: P = 0.73; 24 h: P = 0.92). (b) Body weight change in percent 24 and 48 h post-surgery show no significant difference between BUP-Depot and non-retard formulation using unpaired two-tailed Student t-test (24 h: P = 0.91; 48 h: P = 0.62). Food intake (c) and water intake (d) in gram during baseline measurements, 24, and 48 h post-surgery. Baseline measurements consists of average data from day 1 and day 2 of procedure. No significant difference between non-retard formulation and BUP-Depot group could be found using unpaired two-tailed Student t-test ((c) Baseline: P = 0.69; 24 h: P = 0.34; 48 h: P = 0.78), (d) Baseline: P = 0.54; 24 h: P = 0.88). Only exception was 48 h post-surgery water intake, indicating significant difference between BUP-Depot and non-retard formulation group (P = 0.038). Data is expressed as mean ± SD. (n = 6 per group).