Table 2.
Prognostic Performance of Different Threshold of P0.1 and ΔPocc to Predict Relapse of Respiratory Failure during the Weaning Process of Invasive Mechanical Ventilation
| Thresholds (cm H2O) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR− | Diagnostic Accuracy (%) | Youden Index |
|---|---|---|---|---|---|---|---|---|
| P0.1 | ||||||||
| ≥3 | 89 (52–100) | 47 (24–71) | 44 (22–69) | 90 (55–100) | 1.69 (1.04–2.74) | 0.23 (0.03–1.58) | 61 (41–78) | 0.36 |
| ≥4 | 89 (52–100) | 74 (49–91) | 62 (32–86) | 93 (68–100) | 3.38 (1.54–7.42) | 0.15 (0.02–0.98) | 79 (59–92) | 0.63 |
| ≥5 | 67 (30–93) | 84 (60–97) | 67 (30–93) | 84 (60–97) | 4.22 (1.36–13.16) | 0.40 (0.15–1.02) | 79 (59–92) | 0.51 |
| ≥6 | 67 (30–93) | 84 (60–97) | 67 (30–93) | 84 (60–97) | 4.22 (1.36–13.16) | 0.40 (0.15–1.02) | 79 (59–92) | 0.51 |
| ≥7 | 44 (14–79) | 95 (74–100) | 80 (28–99) | 78 (56–93) | 8.44 (1.10–65.12) | 0.59 (0.32–1.06) | 79 (59–92) | 0.39 |
| ΔPocc | ||||||||
| <−10 | 100 (66–100) | 42 (20–67) | 45 (23–68) | 100 (63–100) | 1.73 (1.18–2.53) | 0.00 (0.00–0.00) | 61 (41–78) | 0.42 |
| <−15 | 67 (30–93) | 68 (43–87) | 50 (21–79) | 81 (54–96) | 2.11 (0.94–4.73) | 0.49 (0.18–1.29) | 68 (48–84) | 0.35 |
| <−20 | 44 (14–79) | 79 (54–94) | 50 (16–84) | 75 (51–91) | 2.11 (0.68–6.58) | 0.70 (0.38–1.32) | 68 (48–84) | 0.23 |
| <−25 | 22 (03–60) | 79 (54–94) | 33 (04–78) | 68 (45–86) | 1.06 (0.24–4.73) | 0.99 (0.65–1.50) | 61 (41–78) | 0.01 |
| <−30 | 11 (00–48) | 89 (67–99) | 33 (01–91) | 68 (46–85) | 1.06 (0.11–10.17) | 0.99 (0.75–1.31) | 64 (44–81) | 0.00 |
Definition of abbreviations: ΔPocc = airway pressure deflection generated by respiratory effort during an end-expiratory airway occlusion; LR+ = positive likelihood ratio; LR− = negative likelihood ratio; NPV = negative predictive value; P0.1 = airway occlusion pressure; PPV = positive predictive value.
Data in parentheses are 95% confidence intervals.