Figure 6.
Effect of rhAC (recombinant human acid ceramidase) treatment on lung inflammation in murine models. (A and B) Number of neutrophils (A) and macrophages (B) in the submucosa of distal large bronchi in lung sections from wild-type, Cftrko, and CftrMHH mice at baseline and after nebulization daily for 3 days with rhAC. Throughout, n = 6 mice in each group. Individual data points are presented along with the mean (horizontal line) ± SD (error bars). For statistical tests used, see the online supplement. ***P ≤ 0.001. WT = wild type.