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. 2020 Oct 14;10:17247. doi: 10.1038/s41598-020-74151-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Preclinical MPI scanner (a) and diagram of experimental workflow (b). (a) Preclinical MPI scanner (MPI 25/20 FF, Bruker BioSpin) in a copper-shielded cabinet to suppress interferences from external electromagnetic fields. (b) Diagram of experimental workflow. First, background MPI signal is acquired, followed by IV injection of one of the MNP and MPI scanning for several minutes. After 1 h (no signals from MNP detectable in blood vessels), the second tracer, was injected intravenously. The order of MNP type administration was random.