Table 3.
Summary of contractile data following 1 min of ischemia or maintained perfusion with or without hypoxia.
| Control (9) | Ischemia (8) | Hypoxia (7) | Stat | |||
|---|---|---|---|---|---|---|
| Diastolic pressure (mmHg) | 12 ± 2.2 | 3.9 ± 1.2 | 24 ± 4.0 | b,c | ||
| Systolic pressure (mmHg) | 107 ± 7.0 | 17.0 ± 2.8 | 74 ± 6.0 | a,b,c | ||
| Developed pressure (mmHg) | 95 ± 7.5 | 13.1 ± 2.1 | 50 ± 7.4 | a,b,c | ||
| Maximum dP/dt (mmHg/s) | 4233 ± 213.8 | 1117.2 ± 181.3 | 3813 ± 783.7 | a,c | ||
| Minimum dP/dt (mmHg/s) | − 2927 ± 120.3 | − 856.0 ± 160.7 | − 1822 ± 148.6 | a,b,c | ||
| RR interval (msec) | 135 ± 11.4 | 383.8 ± 127.6 | 225 ± 54.8 | |||
| Rate pressure product (mmHg/min) | 42,524 ± 2941 | 3060 ± 524 | 15,041 ± 1696 | a,b,c | ||
| Coronary flow (ml/min g) | 124 ± 9.1 | NA | 154 ± 11.7 | b | ||
| Oxygen consumption (µmol O2/min g) | 52 ± 5.6 | NA | 39 ± 3.0 | |||
| Cardiac efficiency (mmHg/µmol O2) | 906 ± 115.0 | NA | 390 ± 33.5 | b | ||
Data mean ± SEM, derived from 7 and 8 hearts for Control and Ischemia conditions respectively. a: P < 0.05 between Control and Ischemia; b: P < 0.05 between Control and Hypoxia; c: P < 0.05 between Ischemia and Hypoxia.