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. 2020 Oct 14;10:17300. doi: 10.1038/s41598-020-74179-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fibrosis can be modulated by currently-used therapeutic drugs. Pre-stimulated (7 days) cells received an anti-fibrotic compound together with either TGF-β or PDGF. Both the collagen levels over time (left column) and the AUC (right column) are depicted. (a) Type I collagen formation in response to TGF-β and iALK5 treatment form day 7. (b) Type I collagen formation in response to TGF-β and nintedanib treatment form day 7. (c) Type VI collagen formation in response to PDGF and nintedanib treatment form day 7. Four technical replicates were used to assess protein levels over time. Tecknical replicates are 4 and data are shown as mean ± SD. Data were analyzed by two-way ANOVA with Dunnett’s multiple comparisons test⁵⁴ and AUC⁵². *P < 0.05, **P < 0.01, ***P < 0.001.