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. 2020 Oct 14;10:17304. doi: 10.1038/s41598-020-74374-5

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© The Author(s) 2020, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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APOBEC 1(DD)-MS2 system induces some off-target C-to-U RNA editing in HEK293 cells. (a) Percentages of expressed genes with at least one edited cytosine (C-to-U or G-to-A) in total SNVs. (b) Box plots showing rate of cytosines edited by APOBEC1(DD)-MS2 compared to control (mutated BFP target in HEK 293 cells), yellow line is median. (c) Jitter plots showing transcriptome-wide efficiencies of C-to-U or G-to-A edits (y-axis) identified from RNA-seq experiments in HEK293 cells

modified by APOBEC1 (DD)-MS2 vs editing- negative control (BFP target, stably transformed in HEK 293 cells). n: total number of modified cytosines identified.