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. 2020 Oct 14;10:17289. doi: 10.1038/s41598-020-74069-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Elevating [Na⁺]_o accelerates the onset of ischemic contracture. Pre-ischemic treatment with SEA0400 further accelerates the onset of ischemic contracture. (A) Representative traces of left-ventricular pressure during 30-min no-flow global ischemia for the 145 Na⁺, 155 Na⁺, and 155 Na⁺ + SEA0400 groups (amplitude full scale normalized for visualization purposes; EDP’—Eq. (1)). (B) Time to peak ischemic contracture for all groups. (C) Diastolic amplitude at time of peak ischemic contracture. (n = 11, 8, and 5 for 145 Na⁺, 155 Na⁺, and 155 Na⁺ + SEA0400, perfusates respectively, * indicates p < 0.05 as determined by a one-way ANOVA with Dunnett’s correction for multiple comparisons to the 155 Na⁺ group).