Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 14;10:17248. doi: 10.1038/s41598-020-74192-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Mdx EDL myofibers are hypertrophic, hypernucleated and have a higher density of myonuclei relative to WT. (A) The length of mdx myofibers is not different from WT mice until 2 years of age, at which time extensive branching architecture occurs in mdx muscles. (B) The diameter of mdx myofibers is larger than age matched WT starting at 24 weeks and continuing through the lifespan. (C) Mdx myofibers become progressively hypertrophic throughout the lifespan and are not susceptible to atrophy in old age. (D) Mdx myofibers become hypernucleated by 12 weeks of age demonstrating recruitment of new myonuclei prior to the onset of hypertrophy. Hypernucleation increases through the first year of life and remains elevated through the lifespan. (E) The myonuclear domain of mdx mice is smaller than WT from 12 to 52 weeks of age indicating a higher density of myonuclei. N = 3 mice and 30 myofibers per group. Analysis via two-way ANOVA with Tukey post hoc test. * = p < 0.05. All data sets are displayed as mean ± s.e.m.