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. 2020 Oct 14;11(10):856. doi: 10.1038/s41419-020-03073-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Low-density hippocampal neurons were infected at 7 DIV with mCherry-tagged Scramble or ShPRRT2 lentivirus in combination with cof-S3E-mCherry or cof-S3A-mCherry. At 14 DIV, mEPSCs were recorded in whole-cell patch-clamp with holding potential of −70 mV. A Representative traces of mEPSCs from all phenotypes tested. B Analysis of mEPSCs. Amplitude, frequency, area, rise 10–90% and 80% decay of mEPSCs are expressed as mean ± SEM of n = number of cells (Scramble = 11, ShPRRT2 = 14, Scr+cof-S3E = 21, Sh+cofS3E = 20, Scr+cof-S3A = 8, Sh+cofS3A = 7 from 3 independent experiments). Amplitude (pA) mean ± SEM: Scramble = 16.90 ± 1.17, ShPRRT2 = 10.24 ± 0.69, Scr+cof-S3E = 18.02 ± 0.96, Sh+cofS3E = 10.30 ± 0.59, Scr+cof-S3A = 17.62 ± 1.65, Sh+cofS3A = 9.94 ± 0.68, p < 0.001 Scramble vs ShPRRT2, p < 0.001 Scr+cofS3E vs Sh+cof-S3E, p < 0.01 Scr+cofS3A vs Sh+cof-S3A; frequency (Hz): Scramble = 3.93 ± 0.72, ShPRRT2 = 1.24 ± 0.40, Scr+cof-S3E = 4.12 ± 0.64, Sh+cofS3E = 1.26 ± 0.25, Scr+cof-S3A = 3.36 ± 0.56, Sh+cofS3A = 1.11 ± 0.46, p < 0.05 Scramble vs ShPRRT2, p < 0.001 Scr+cofS3E vs Sh+cof-S3E, p < 0.05 Scr+cofS3A vs Sh+cof-S3A; area (pA*ms): Scramble = 63.28 ± 3.72, ShPRRT2 = 34.24 ± 3.13, Scr+cof-S3E = 52.27 ± 3.65, Sh+cofS3E = 31.44 ± 3.14, Scr+cof-S3A = 53.37 ± 5.44, Sh+cofS3A = 27.75 ± 2.75; p < 0.001 Scramble vs ShPRRT2, p < 0.001 Scr+cofS3E vs Sh+cof-S3E, p < 0.05 Scr+cofS3A vs Sh+cof-S3A; rise 10–90 (ms): Scramble = 1.28 ± 0.08, ShPRRT2 = 1.31 ± 0.08, Scr+cof-S3E = 0.94 ± 0.05, Sh+cofS3E = 1.26 ± 0.11, Scr+cof-S3A = 0.96 ± 0.07, Sh+cofS3A = 1.22 ± 0.09; 80% decay (ms): Scramble = 5.13 ± 0.26, ShPRRT2 = 4.18 ± 0.28, Scr+cof-S3E = 3.96 ± 0.16, Sh+cofS3E = 3.78 ± 0.37, Scr+cof-S3A = 4.47 ± 0.55, Sh+cofS3A = 3.34 ± 0.27. Statistical analysis was conducted with Student’s t-test (Scramble vs ShPRRT2 couples); *p < 0.05, **p < 0.01, ***p < 0.001.