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Conserved residues identified across members of the superfamily
| Subfamily | Position 1 | Position 2 | Substrate |
|---|---|---|---|
| (6–4) photolyase | H | W | 6–4 |
| Animal Cry | H | W | – |
| CPD class I | M | W | CPD |
| CPD class II | M | W | CPD |
| CPD class III | M | W | CPD |
| Cry-DASH | Q | Y | ssDNA |
| Plant Cry | V | Y | – |
| Plant photolyase | – | – |
