Table 2.
Gene | Description | Function | Fold change | p value* |
---|---|---|---|---|
Upregulated | ||||
FZD4 | Frizzled homolog 4 | Wnt coreceptor | 54.68 | 0.0007 |
WNT4 | Wingless-type MMTV integration site family, member 4 | Noncanonical WNT signaling; embryogenesis | 18.82 | 0.0092 |
LEF1 | Lymphoid enhancer-binding factor 1 | Transcription factor in the Wnt pathway | 14.82 | 0.0071 |
LRP5 | Low density lipoprotein receptor-related protein 5 | Wnt coreceptor | 11.85 | 0.0071 |
NKD1 | Naked cuticle homolog 1 | Antagonist of Wnt signaling; binds DVL enabling GSK3B-dependent phosphorylation and ubiquitination of β-catenin | 11.79 | 0.0071 |
CSNK2A2 | Casein kinase 2, alpha prime polypeptide | Cytoplasmic and nuclear stimulator of Wnt signaling; suppresses β-catenin degradation, enhances β-catenin:LEF1 transactivation of Wnt target genes | 11.20 | 0.0012 |
SFRP4 | Secreted frizzled-related protein 4 | Secreted Wnt antagonist. Suppresses both canonical and noncanonical signaling | 9.28 | 0.0071 |
FZD6 | Frizzled homolog 6 | Wnt coreceptor | 8.73 | 0.0305 |
AXIN2 | Axin 2 | Antagonist of Wnt signaling; sequesters β-catenin in a multiprotein destruction complex | 6.69 | 0.0449 |
DKK3 | Dikkopf homolog 3 | Secreted Wnt antagonist. Divergent member of DKK family; does not appear to function directly in Wnt signaling | 5.15 | 0.0508 |
APC | Adenomatosis polyposis coli | Antagonist of Wnt signaling; sequesters β-catenin in a multiprotein complex | 4.76 | 0.0092 |
GSK3β | Glycogen synthase kinase 3 beta | Antagonist of Wnt signaling; Phosphorylates β-catenin for proteasomal degradation | 3.77 | 0.0217 |
DVL3 | Disheveled, dsh homolog 3 | Phosphoprotein, stimulates Wnt signaling; inhibits activity of GSK3β | 2.95 | 0.0217 |
Downregulated | ||||
FZD1 | Frizzled homolog 1 | Wnt receptor | 6.56 | 0.0449 |
FZD8 | Frizzled homolog 8 | Wnt receptor | 4.15 | 0.0476 |
p value is adjusted for false discovery. Only those genes with a significant change in expression are listed in this table.