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Synthesis of compound 18. Reagents and Conditions: (a) 66% aq, methylamine, methanol, reflux, 2 hr; (b) lithijm aluminum hydride, tetrahydrofuran; (c) chloroacetyl chloride, pyridine, benzene, reflux 3 hr; (d) cyclic amine, 100°C; (e) iodomethane, methanol, reflux, 18 hr.
