Figure 2.

Omics Strategies for Biomarker Discovery

Clinically informed, omics-based investigations using biological samples, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and immunolomics, combined with advances in bioinformatics and computational tools may provide an unparalleled opportunity for the discovery of novel, molecularly targeted biomarkers. ATAC-seq = assay for transposase-accessible chromatin sequencing; CHIP = clonal hematopoiesis of indeterminate potential; ChIP-seq = chromatin immunoprecipitation sequencing; CyTOF = cytometry by time-of-flight; lncRNA = long noncoding RNA; mRNA = messenger RNA; miRNA = microRNA; NGS = next-generation sequencing; piRNA = piwiRNA; seq = sequencing; SNP = single nucleotide polymorphism; WGS = whole-genome sequencing.