Table 4:

Malaria Chemoprophylaxis in Pregnancy

Generic Name	Dose Regimen	Duration of Prophylaxis	Contraindications
Chloroquine Hydroxychloroquine	• 300 mg base (500mg salt) orally, once/week  • 310mg base (400mg salt) orally, once/week	• Begin 1–2 weeks before travel to malarious areas.  • Take weekly on the same day of the week while in the malarious area  • Continue for 4 weeks after leaving such areas.	• Avoid use in chloroquine-resistant regions  • Hypersensitivity to chloroquine and 4-aminoquinoline compounds  • The presence of retinal or visual field changes of any etiology.a
Mefloquine	• 228 mg base (250 mg salt) orally, once/week	• Begin ≥2 weeks before travel to malarious areas.  • Take weekly on the same day of the week while in the malarious area  • Continue for 4 weeks after leaving such areas.	• Hypersensitivity to mefloquine, related compounds  • Patients with a history of seizures or psychiatric disorder.b

^a.Specifically when used for indications other than acute malaria

^b.Including active or recent history of depression, generalized anxiety disorder, psychosis, schizophrenia, or other major psychiatric disorders

Compiled from CDC Guidelines¹¹ and Cash-Goldwasser et. al⁴⁰.