Table 5:

Intermittent Preventive Treatment in Pregnancy

Generic Name	Dose Regimen	Duration of Prophylaxis	Side Effects
Sulfadoxine-pyrimethamine	• 500 mg sulfadoxine/25 mg pyrimethamine  • Take 3 tablets as one dose (1,500mg/75mg)	• Take 3 doses qlmonth starting early 2nd trimester	• Nausea  • Abdominal Pain  • Diarrhea  • Headache  • Liver toxicity (rare)a  • Hematologic toxicity (rare)b  • Hypersensitivity to sulfadoxine component (rare)
Dihydroartemisinin-piperaquine	• 40mg dihydroartemisinin/320mg piperaquine  • Take 3 tablets, as one dose, daily for three consecutive days	• Take daily x3 consecutive days every 4 weeks starting at 16–20 weeks	• Post-treatment headache  • Weakness  • Dizziness  • Nausea  • Vomiting  • Insomnia  • Palpitations  • Dyspnea  • Nightmares  • Pruritus

^a.Hepatitis, acute hepatic necrosis

^b.Thrombocytopenia, leucopenia, megaloblastic anemia

Compiled from Deloron et.al⁴⁶, WHO Guidelines⁴², Chattopadhyay et. al³⁷, and Kakuru et. al⁴⁴.