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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: J Med Chem. 2019 Dec 16;62(24):11348–11358. doi: 10.1021/acs.jmedchem.9b01685

Fig. 8. A common mechanism of mitochondria uncoupler and glycolytic inhibitor on AMPK activation and Wnt signaling inhibition.

Fig. 8.

A and B. Mitochondrial uncoupler FCCP activated AMPK and inhibited Wnt signaling. C and D. Glycolytic inhibitor 2-DG activated AMPK, inhibited Wnt signaling. E. Effects of 2-DG (10 mM) on ATP levels in LS174T cells. F. FTU-11 and FH535 reduced LiCl-induced β-catenin accumulation in LS174T cells.