TABLE 3.
List of parameter values.
| Parameter | Description | Value (h−1) | Source |
|---|---|---|---|
| k1f | Rate of β1 integrin adhesion and activation | 23 | Estimated from Ref. 49 |
| k1r | Rate of β1 integrin deactivation | 0.567 | Estimated from Ref. 49 |
| k2f | Rate of β3 integrin adhesion and activation | 23 | Estimated from Ref. 49 |
| k2f | Rate of β3 integrin deactivation | 0.567 | Estimated from Ref. 49 |
| k3f | Rate of TGF-β1 ligand attachment to TBR2 receptor | 60 | Ref. 44 |
| k3r | Rate of TGF-β1 disassociation | 15 | Estimated from Ref. 44 |
| kIpF | Rate of β1 integrin activation of FAK | 0.454 | Estimated from Refs. 13,49 |
| kIpS | Rate of β3 integrin activation of Src | 20.15 | Estimated from Refs. 1,49 |
| kTpS | Rate of TGFβ receptor activation of Src | 120 | Estimated from Refs. 14,15,21 |
| kSpF | Rate of Src association with FAK and activation of secondary phosphorylation sites | 29 | Estimated from Refs. 7,41,49 |
| KmSF | Michaelis–Menten constant for Src activation of FAK | 0.1 | Estimated from Ref. 7 |
| kFAKpE | Rate of FAK activation of ERK | 48 | Estimated from Refs. 46,49 |
| kFGFpFAK | Rate of FGF activation of FAK | [2.2–8.4] | Estimated from Refs. 17,29 and optimized |
| kFGFpERK* | Rate of FGF activation of ERK | [5.5–16.6] | Estimated from Refs. 17,29 and optimized |
| kSpT | Rate of Src phosphorylation of TBR2 | 40 | Estimated from Refs. 14,15 |
| KmST | Michaelis–Menten constant for Src activation of TBR2 | 0.1 | Estimated from Refs. 14,15 |
| kSpP | Rate of Src phosphorylation of p38 | 10 | Estimated from Refs. 7,41,49 |
| kTpP* | Rate of TGF-β1 activation of pp38 | [13.3–371] | Estimated from Refs. 14,15 |
| kIpP* | Rate of β1 integrin activation of p38 | 5 | Estimated from Refs. 24,33 |
| kPr | Rate of p38 dephosphorylation | 580 | Ref. 30 |
| kEr | Rate of ERK dephosphorylation | 210 | Estimated from Ref. 49 |
| kSr | Rate of Src dephosphorylation | 432 | Estimated from Ref. 49 |
| kFr | Rate of FAK dephosphorylation | 48 | Estimated from Ref. 49 |
| kTr | Rate of ligand induced TBR2 deactivation | 15 | Ref. 44 |
| kE | Intrinsic rate of ERK activation | 2 | Estimated and optimized |
| kαSMAf* | Rate of p38 promotion of αSMA | 0.5 | Estimated and optimized for each model |
| kαSMAr | Rate of αSMA degradation | 0.515 | Estimated from Ref. 20 |
Initial estimates of values were calculated from literature and varied to find the optimal parameter set.
Parameters that were optimized to calibration data set indicated by *.