Fig. 3.

Sensitivity to LPS exposure is mildly affected by mitochondrial respiratory chain function. (A) Dose-dependent increase in IL-6 levels and LPS EC₅₀ (LPS concentration necessary to reach the half-maximal IL-6 levels) measured in whole blood. (B) Effect of mitochondrial respiratory chain inhibitors on EC₅₀ relative to LPS alone. Negative values represent sensitization (low EC₅₀) and positive values represent suppression (high EC₅₀) of LPS-response. Effect sizes computed as Cohen’s d. Data presented are mean ​± ​SEM, n ​= ​20.