Fig. 6.

Glucocorticoid signaling suppresses most LPS-induced pro-inflammatory cytokines and increases IL-10. (A) Experimental design to probe DEX-mediated effects on cytokine signatures. (B) Effect of DEX on LPS-induced inflammatory cytokine responses relative to LPS alone. The cytokines are ordered from most-to least-suppressed by DEX. (C) Fold change in cytokine response to LPS by DEX exposure relative to LPS alone. P values from one-way ANOVA. (D) % DEX suppression of stimulated IL-6, paired t-test, n ​= ​19–20. (E–H) Effect of respiratory chain inhibitors on %DEX-suppression. Effect sizes (Cohen’s d) and % changes in DEX-suppression are presented, with P values from paired t-test. Data are means ​± ​SEM, n ​= ​20 except in E-H where n ​= ​15–16.