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. 2020 Oct 5;18(10):e3000850. doi: 10.1371/journal.pbio.3000850

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© 2020 Kobia et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — A. Normal heart with complete septum. B. N1^RA/–; N2^RA/–heart with a severe, highly penetrant VSD. The penetrance by age shown below the image. C. N1^RA/–; N2^+/RA heart with a milder, less penetrant VSD. E, embryonic day; N1^RA/–; N2^+/RA, Notch1 Arg¹⁹⁷⁴Ala Notch2 Arg¹⁹³⁴Ala hemizygous; VSD, ventricular septal defect.