Table 1. Characteristics of the 670 nondiabetic children and adolescents who participated in the SAFARI study, association between Acanthosis Nigricans (AN) and overweight, obese, prediabetes, and metabolic syndrome conditions, and heritability estimate for Acanthosis Nigricans severity scores (AN-q).
| Variablea | N | Mean ± SD or % | Acanthosis nigricans (AN) | |||
|---|---|---|---|---|---|---|
| % | ORc | 95% CIc | P value | |||
| Girls | 670 | 49.3 | - | - | - | - |
| Age (years) | 670 | 11.5 ± 3.5 | - | - | - | - |
| BMI (kg/m2) | 670 | 24.7 ± 6.5 | - | - | - | - |
| Normal weight | 670 | 47.3 | 10.6 (33/278) | 0.11 | 0.07–0.16 | <0.001 |
| Overweight | 670 | 19.1 | 53.1 (186/164) | 9.6 | 6.3–14.5 | <0.001 |
| Obese | 670 | 33.6 | 65.3 (145/77) | 9.3 | 6.4–13.5 | <0.001 |
| Prediabetes | 630 | 13.2 | 47.0 (39/44) | 1.9 | 1.2–3.0 | 0.008 |
| Metabolic syndrome (MS) | 625 | 18.7 | 67.0 (77/38) | 5.7 | 3.7–8.8 | <0.001 |
| Acanthosis nigricans (AN) | 661 | 33.1 | - | - | - | - |
| AN severity score (AN-q)d | 660 | 1.3 ± 1.7 | - | - | - | - |
aSee text for definitions, and the obesity/CMRFs used in the study were described previously by Fowler et al. 2013, and some were adapted from it for description in this table
badjusted for the age, sex, and pubertal-status effects
cOR = odds ratio and 95% CI = 95% Confidence Intervals. The ORs were calculated with a total of 661 children with complete data
dHeritability (h2) of AN-q = 0.75 (please see text.