Table 2. Phenotypic (ρP), genetic (ρG), and environmental (ρE) correlations between Acanthosis Nigricans severity scores (AN-q) and obesity-related traits.
| Trait | ρP | ρG | ρE | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PE | SE | p-Value | PE | SE | p-Value | PE | SE | p-Value | |
| BMI (kg/m2)a | 0.65 | 0.025 | 1 x 10−58 | 0.72 | 0.07 | 2 x 10−08 | 0.36 | 0.27 | 0.321 |
| WC (mm) | 0.66 | 0.020 | 9 x 10−63 | 0.79 | 0.07 | 1.1 x 10−07 | 0.45 | 0.17 | 0.101 |
| SBP (mm Hg) | 0.20 | 0.041 | 1.8 x 10−06 | 0.30 | 0.12 | 0.022 | -0.04 | 0.25 | 0.886 |
| DBP (mm Hg) | 0.14 | 0.040 | 0.0011 | 0.30 | 0.13 | 0.026 | -0.20 | 0.25 | 0.393 |
| TG (mg/dl)a | 0.31 | 0.039 | 9.8 x 10−13 | 0.41 | 0.11 | 0.0008 | -0.09 | 0.35 | 0.822 |
| HDL-C (mg/dl) | -0.22 | 0.042 | 3.0 x 10−07 | -0.25 | 0.13 | 0.064 | -0.17 | 0.25 | 0.528 |
| FG (mg/dl)a | 0.02 | 0.043 | 0.6603 | -0.02 | 0.17 | 0.923 | 0.07 | 0.19 | 0.717 |
| FI (μIU/ml)a | 0.31 | 0.039 | 2 x 10−13 | 0.46 | 0.13 | 0.0013 | 0.06 | 0.22 | 0.802 |
| HOMA-IRb | 0.31 | 0.039 | 2 x 10−13 | 0.40 | 0.12 | 0.003 | 0.14 | 0.23 | 0.591 |
| CRP (ng/ml)b | 0.26 | 0.042 | 3.5 x 10−09 | 0.38 | 0.16 | 0.032 | 0.17 | 0.19 | 0.412 |
| PFSb | -0.35 | 0.041 | 3.4 x 10−14 | -0.57 | 0.13 | 0.0001 | 0.15 | 0.29 | 0.578 |
aTraits were log transformed for the genetic analyses
btraits were inverse normalized for the genetic analyses. All traits were adjusted for sex, age, and pubertal-status effects; BMI = body mass index; WC = waist circumference; SBP = systolic blood pressure; DBP = diastolic blood pressure; TG = triglycerides; HDL-C = high density lipoprotein cholesterol; FG = fasting plasma glucose; FI = fasting insulin; HOMA-IR = homeostasis model of assessment-insulin resistance; CRP = high-sensitivity C-reactive protein; PFS = Harvard physical fitness score.