Table 3. List of parameters of the mathematical model for NSCLC patients.

symbol	value	description	reference
DTs	5–1000 days	Doubling time of sensitive cells	Fitted to clinical data
λs	ln(2)/DTs[1/day]	Growth rate of sensitive cells	Fitted to clinical data
λr	0.5 ·λs[1/day]	Growth rate of res. cells	We assume that resistant cells grow twice smaller than sensitive ones
K	30 cm diameter	Carrying capacity	[17]
asr	0	Competition coefficient	For model calibration we set the parameter to zero (for simplification of the model calibration). In other analyzes we simulated the model for various values of asr.
ars	0	Competition coefficient	For model calibration we set the parameter to zero (for simplification of the model calibration). In other analyzes we simulated the model for various values of ars.
Mdiagnosis	4 cm diameter	Tumor burden at the diagnosis	[17]
σ	0–1	Fraction of resistant cells at diagnosis	Varied
Mdeath	15 cm diameter	Lethal tumor burden	[36]
T	21 [days]	Time interval between two consecutive cycles of chemotherapy	Fitted to clinical data
k	0.211	Clearance rate of cisplatin	Half-life of cisplatin is 80 hours
Cmax	20 [A.U.]	Dose of chemotherapy	Fitted to clinical data
CTcycles	0–6	Number of chemotherapy cycles	Fitted to clinical data