Table 5. Associations of ONID risk with genotype and allele distributions of PON3 polymorphisms.
| SNPs | Models | Total (n = 300) | ONID group | Control group (n = 150) | P value | Crude OR | Adjusted OR* |
|---|---|---|---|---|---|---|---|
| (n = 150) | (95% CI) | (95% CI) | |||||
| rs11767787 | Genotype | 0.013 | |||||
| TT | 211(70.33) | 96(64) | 115(76.67) | 1 | 1 | ||
| CT | 89(29.67) | 54(36) | 35(23.33) | 2.12(1.19–3.77 | 2.12(1.18–3.84) | ||
| Allele | 0.013 | ||||||
| T | 511(85.17) | 246(82) | 265(88.33) | 1 | 1 | ||
| C | 89(14.83) | 54(18) | 35(11.67) | 1.65(1.05–2.6) | 1.68(1.06–2.66) | ||
| rs13226149 | Genotype | 0.003 | |||||
| GG | 211(70.33) | 93(62) | 118(78.67) | 1 | 1 | ||
| AG | 89(29.67) | 57(38) | 32(21.33) | 2.09(1.27–3.43) | 2.09(1.25–3.47) | ||
| Allele | 0.003 | ||||||
| G | 511(85.17) | 243(81) | 268(89.33) | 1 | |||
| A | 89(14.83) | 57(19) | 32(10.67) | 1.86(1.19–2.91) | 1.87(1.19–2.93) | ||
| rs17882539 | Genotype | 0.0009 | |||||
| CC | 215(71.67) | 95(63.33) | 120(80) | 1 | 1 | ||
| CT | 85(28.33) | 55(36.67) | 30(20) | 2.56(1.44–4.57) | 2.59(1.44–4.67) | ||
| Allele | 0.0009 | ||||||
| C | 515(85.83) | 245(81.67) | 270(90) | 1 | |||
| T | 85(14.17) | 55(18.33) | 30(10) | 1.97(1.23–3.16) | 1.95(1.22–3.14) |
The numbers in the parentheses are % in columns 3, 4, and 5.
SNP, single nucleotide polymorphism; ONID, occupational noise-induced deafness; OR, odds ratio; 95% CI, 95% confidence interval.
*Adjusted for age, smoking, drinking, BMI, exposure time and noise exposure level in the conditional logistic regression model.