Table 2.
Mixed meal tolerance test parameters for healthy pregnant control subjects (HP) study day 1 (SD1, baseline) and study day 2 (SD2)
| HP (n = 28) | |||
|---|---|---|---|
| Parameter | SD1 | SD2 | Δ |
| SI (10−4 min−1 μU−1 mL) | 8 ± 6 (2 to 20) | 7 ± 4 (1 to 20) | −0.8 ± 4 (−9 to 6) (p=0.6) |
| Φtotal (10−9 min−1) | 120 ± 60 (51 to 280) | 110 ± 40 (46 to 190) | −10 ± 50 (−100 to 20) (p=0.1) |
| Φstatic (10−9 min−1) | 100 ± 50 (30 to 200) | 80 ± 30 (30 to 200) | −10 ± 40 (−100 to 30) (p=0.1) |
| Φdynamic 10−9) | 3,000 ± 2,000 (1,000 to 7,000) | 3,000 ± 1,000 (1,000 to 5,000) | 2 ± 1,000 (−2,000 to 2,000) (p=1) |
| Φbaseline (10−9 min−1) | 10 ± 4 (4.3 to 20) | 14 ± 6 (6.2 to 26) | 3 ± 3 (−0.2 to 9) (p < 0.001) |
| DI (10−13 min−2 μU−1 mL) | 800 ± 500 (200 to 2,000) | 600 ± 300 (200 to 1,000) | −200 ± 400 (−1,000 to 400) (p=0.04) |
| Peak Glucose (mg/dL) | 120 ± 20 (94 to 150) | 120 ± 10 (96 to 150) | −0.7 ± 10 (−30 to 10) (p=0.8) |
Results reported as mean ± SD (95% confidence interval)
Δ = average change between study day 1 and study day 2, SI = Insulin sensitivity, Φ = β-cell responsivity and DI = Disposition index.