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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Bioorg Med Chem. 2013 Feb 27;21(9):2623–2634. doi: 10.1016/j.bmc.2013.02.020

Scheme 4.

Scheme 4.

Reagents and conditions: (a) acid (1.05 equiv), DCC (2 equiv), DCM, rt, overnight, 90–99%; (b) TFA/CH2Cl2 (v/v, 1/1), rt, 1 h; (c) DMAP (0.2 equiv), Et3N (1.5 equiv), Ac2O (1.9 equiv), DMF, 80 °C, 24 h, 69–76%.