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Vitamin B12 modulates the transcription of Met/SAM cycle genes and controls in/efflux through the sensing of SAM by nhr-114. Dashed arrows indicate regulation of metabolic activity. Solid arrows indicate transcriptional regulation. Vitamin B12 increases Met/SAM cycle metabolic activity producing SAM, which represses nhr-114 transcription thereby reducing the expression of Met/SAM cycle related genes.
