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. 2020 Sep 30;11:582010. doi: 10.3389/fimmu.2020.582010

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Copyright © 2020 Niu, Li, Li, Pan, Wang, Feng, Mo, Yan, Ye, Luo, Qu, Weber, Byrne-Steele, Wang, Yu, Li, Myers, Lotze, Zhong, Han and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treemap plots of TCR and BCR repertoires in PBMCs of ICU patients. (A) Treemap plots of the seven individual adaptive immune chains from patient 4 and patient 5 on day 4 following symptoms onsets. The control treemap plot was from the same healthy person before vaccination with a seasonal quadrivalent influenza vaccine. (B) Treemap plots containing total TRB unique CDR3 clonotypes, each represents patients 4, patient 5, and a healthy control. A rectangle in a treemap plot represents a unique clonotype. The size of a rectangle denotes the relative frequency of an individual CDR3 sequence. The color of the individual CDR3 sequence in each Treemap plot was randomly chosen, and thus, the colors do not match between the plots.