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. 2020 Sep 30;10:557737. doi: 10.3389/fonc.2020.557737

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Copyright © 2020 van Huizen, Burgers, van Rosmalen, Doukas, IJzermans and Luider.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The average number of hydroxylations per peptide. Tested for differences with a repeated paired t-test. P-values below 0.05/6 = 0.0083 are considered significant. (B) Absolute difference in the average number of hydroxylations per peptide with respect to colon tissue. P-values below 0.05/3 = 0.0167 are considered significant. (C) Relative difference in the number of hydroxylations with respect to colon tissue. The “X” in the legend of the Y-axis represents CRC, CRLM, or liver tissue, depending on the comparison made. Only significant values are presented as horizontal bars in (A) and (B).