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. 2020 Sep 30;11:575488. doi: 10.3389/fimmu.2020.575488

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Copyright © 2020 Cruz-Barrera, Flórez-Zapata, Lemus-Diaz, Medina, Galindo, González-Acero, Correa, Camacho, Gruber and Salguero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of novel functional markers of immune-modulatory UC.MSC. (A) Expression of CD146, CD271, and CD276 in UC-MSC under basal conditions or exposed to activated PBMNC for 5 days. (B) Expression of adhesion molecules CD106, CD54, CD44, CD49f, and CD49e in UC-MSC under basal conditions or exposed to activated PBMNC in cell contact (cc) or transwell (tw) setting for 5 days (* vs. Basal, p < 0.05, n = 4–6). (C) Detection of IL-2R in cell membrane, intracellular and in supernatants of UC-MSC treated with PHA, αCD3/CD28, TNFα/IL1b (CK), PHA and αCD3/CD28-activated PBMNC/MSC (* vs. Basal, p < 0.05, n = 4–6).