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. 2020 Sep 30;10:571944. doi: 10.3389/fonc.2020.571944

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Copyright © 2020 Zhang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lysine acetylation occurs through lysine acetyltransferase (KAT)-catalyzed transfer of an acetyl group from acetyl-CoA to the ε-amino side chain of lysine. Alternatively, acetyl-CoA can acetylate lysine non-enzymatically. Acetylation is reversed by Zn2+-dependent histone deacetylases (HDACs), or by the NAD+-dependent sirtuin family of deacetylases. HDAC-catalyzed deacetylation generates deacetylated lysine and acetate, whereas sirtuin-catalyzed deacetylation produces deacetylated lysine, nicotinamide and 2’ or 3’-O-acetyl-ADP-ribose (7).