TABLE 2.

Association between 10-years increase in age and proportions of T-cell subsets.

PLWH					Uninfected controls
T-cell subsets	Model 1	p	Model 2	p	Model 1	p
CD4+ activation	−6.7% (−9.5; −3.9)	<0.001	−5.8 (−8.6; −1.9)	0.001	2.02% (−14.8; 22.2)	0.821
CD8+ activation	−2.9% (−4.8; 0.0)	0.028	−2.0 (−4.9; 1.0)	0.297	7.3% (−7.8; 24.6)	0.347
CD4+ senescent	16.2% (7.3; 27.1)	0.001	25.9 (13.9; 39.1)	<0.001	46.2% (−3.0; 120.3)	0.074
CD8+ senescent	11.6% (6.2; 16.2)	<0.001	16.2 (10.5; 22.1)	<0.001	22.14% (−4.9; 56.8)	0.122
CD4+ apoptotic	18.5% (10.5; 25.9)	<0.001	20.9 (11.6; 31.0)	<0.001	18.5% (−10.4; 58.4)	0.239
CD8+ apoptotic	12.8% (8.3; 17.4)	<0.001	16.2 (10.5; 20.9)	<0.001	24.6% (0.0; 55.3)	0.061

Model 1 was adjusted for sex, BMI group and smoking status. Model 2 was further adjusted for CD4+ nadir and time on cART. All T-cell subsets were log transformed before analyzed. Activation (CD38+ HLA-DR+), senescent (CD28-CD57+), and apoptotic (CD28-CD95+).