Table 1.
Summary of FDA-approved drugs that have been or being repurposed for treatment of Alzheimer’s disease.
| Drug Class | Treatment | Drug | Phase and Clinicaltrials.gov Identifier |
|---|---|---|---|
| Cardiovascular disorder | Cerebrovascular circulatory disorders | Dihydroergocristine (DB13345)258 | Investigational |
| Hypertension | Valsartan (DB00177)96 | Investigational | |
| Hypertension | Isradipine (DB00270)101 | Investigational | |
| Hypertension | Telmisartan (DB00966)259 | Phase I (NCT02471833) | |
| Hypertension | Perindopril (DB00790)260 | Phase II (NCT02085265) | |
| Hypertension | Losartan (DB00678)261 | Phase III (NCT02913664) | |
| Hypertension | Carvedilol (DB01136)99 | Phase IV (NCT01354444) | |
| Hypertension | Nilvadipine (DB06712)262 | Phase IV (NCT02017340) | |
| Hypertension | Nimodipine (DB00393)263 | Phase IV (NCT00814658) | |
| Metabolic disorder | Diabetes Mellitus | Liraglutide (DB06655)46 | Phase II (NCT01843075) |
| Diabetes Mellitus | Metformin (DB00331)264 | Phase II (NCT00620191) | |
| Diabetes Mellitus | Pioglitazone (DB01132)265 | Phase II (NCT00982202) | |
| Diabetes Mellitus | Benfotiamine (DB11748)266 | Phase II (NCT02292238) | |
| Hypercholesterolemia | Pitavastatin (DB08860)48 | Phase II (NCT00548145) | |
| Hypercholesterolemia | Atorvastatin (DB01076)48 | Phase II (NCT02913664) | |
| Hypercholesterolemia | Simvastatin (DB00641)267 | Phase II (NCT01439555) | |
| Nervous systems or mental disorders | Erectile dysfunction | Sildenafil (DB00203)102 | Investigational |
| Erectile dysfunction | Tadalaril (DB00820)268 | Phase II (NCT02450253) | |
| Aamyotrophic lateral sclerosis | Riluzole (DB00740)269 | Phase II (NCT01703117) | |
| Depressive disorder | Paroxetine (DB00715)270 | Investigational | |
| Parkinson | Rasagiline (DB01367)271 | Phase II (NCT02359552) | |
| Schizophrenia | Clozapine (DB00363)225 | Investigational | |
| Epilepsy | Levetiracetam (DB01202)272 | Phase II (NCT03489044) | |
| Urea cycle disorders | Benzoic Acid (DB03793)273 | Phase II (NCT01600469) | |
| Others | Cutaneous T cell lymphoma | Bexarotene (DB00307)274 | Phase II (NCT01782742) |
| Acute promyelocytic leukaemia | Tamibarotene (DB04942)275 | Phase II (NCT01120002) | |
| Infections | Minocycline (DB01017)50 | Phase II (NCT01463384) | |
| Malaria | Methylene blue (DB09241)276 | Phase II (NCT02380573) | |
| Mast cell tumors in animals | Masitinib (DB11526)277 | Phase III (NCT01872598) | |
| Psoriasis | Acitretin (DB00459)278 | Phase II (NCT01078168) | |
| Severe acne | Isotretinoin (DB00982)279 | Phase II (NCT01560585) |