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The unclear relationship between Ras, PI3K and mTORC2. Ras is activated by many different stimuli and its intracellular effectors include class 1 phosphatidylinositol 3-kinases (PI3Ks) that produce PI(3,4,5)P3 and, as recently identified, mTORC2. Several studies suggest that PI(3,4,5)P3 promotes mTORC2 activation. Whether Ras and PI3K cooperate to fully activate mTORC2 or whether they act independently to promote mTORC2 activation is still debated.
