Figure 4.

Representative AS Events and Genes Altered Following Loss of SRSF1 in Skeletal Muscle

(A–C) Representative AS events regulated by SRSF1 in the P30 skeletal muscle. Validated RT-PCR results are shown with alternative exons included or skipped in response to loss of SRSF1 (n = 3).

(D) Seven AS events shown in (A–C) were further examined in muscles isolated from P1, P15, or P30 control and MKO mice (n = 3).

(E) Three groups of genes with significant changes in MKO mice. Fold changes of RNA-seq reads mapping to related genes were calculated between MKO and control samples.