Table 1.
Overview of assays
| First tier | Second tier | ||||||
|---|---|---|---|---|---|---|---|
| Abbr. | Name and manufacturer | Antibody | Antigen | Abbr. | Name and manufacturer | Antibody | Antigen |
| Enz1 | Enzygnost borreliosis (Siemens, Eschborn, Germany) | IgM | Detergent extract of Bafz PKo | RecomL (STTT) | RecomLine Borrelia (Mikrogen, Neuried, Germany) | IgM | 15 rec. proteins of Bbss, Bafz Bbav, Bspiel and Bgar |
| IgG | Identical | ||||||
| Enz2 | Enzygnost borreliosis Lyme Link (Siemens, Eschborn, Germany) | IgM | Detergent extract of Bafz PKo | ||||
| IgG | Identical, with added mix of 3 rec. VlsE variants | IgG | 15 rec. proteins of Bbss, Bafz, Bbav, Bspiel and Bgar | ||||
| Lia | Liaison B. burgdorferi (DiaSorin, Saluggia, Italy) | IgM | rec. OspC of Bafz PKo and rec. VlsE of Bbav PBi | ||||
| IgG | rec. VlsE of Bbav PBi | ||||||
| C6 | C6 Lyme ELISA (Immunetics, Boston, USA) | IgM/IgG | rec. VlsE (IR6) of Bbss | C6 (MTTT) | C6 Lyme ELISA (Immunetics, Boston, USA) | IgM/IgG | rec. VlsE (IR6) of Bbss |
Bafz, B. afzelii; Bbav, B. bavariensis; Bgar, B. garinii; Bbss, B. burgdorferi sensu stricto; Bspiel, B. spielmanii; ELISA, enzyme-linked immunosorbent assay; OspC, outer-surface protein C; rec., recombinant; VlsE, variable major protein-like sequence, expressed