Table 4.
Diagnostic odds ratios of all algorithms
| Single-tier DOR (95%-CI) |
STTT DOR (95%-CI) |
MTTT-strict DOR (95%-CI) |
MTTT-permissive DOR (95%-CI) |
|||
|---|---|---|---|---|---|---|
| DOR with PopC sera | ||||||
| Enz1 | 30.9 (18.1–52.1) | Enz1/RecomL | 27.8 (12.5–61.6) | Enz1/C6 | 68.4 (32.0–146.5) | 69.5 (34.4–140.3) |
| Enz2 | 34.5 (20.3–58.4) | Enz2/RecomL | 27.8 (12.5–61.6) | Enz2/C6 | 74.6 (34.8–160.1) | 85.6 (41.0–178.6) |
| Lia | 23.5 (13.8–40.0) | Lia/RecomL | 29.8 (12.7–69.9) | Lia/C6 | 56.9 (26.6–121.3) | 53.6 (27.3–104.9) |
| C6 | 51.3 (27.9–94.4) | C6/RecomL | 30.3 (12.9–71.2) | |||
| DOR with CRC sera | ||||||
| Enz1 | 7.3 (3.7–14.2) | Enz1/RecomL | 7.8 (2.9–20.4) | Enz1/C6 | 15.1 (6.5–35.2) | 14.3 (6.5–31.3) |
| Enz2 | 8.1 (4.2–15.9) | Enz2/RecomL | 7.8 (2.9–20.4) | Enz2/C6 | 16.5 (7.0–38.5) | 15.8 (7.2–34.6) |
| Lia | 3.8 (2.0–7.3) | Lia/RecomL | 5.8 (2.4–14.2) | Lia/C6 | 12.5 (5.4–29.2) | 14.0 (6.2–31.6) |
| C6 | 21.6 (6.0–26.4) | C6/RecomL | 9.3 (3.2–26.7) | |||
DOR, diagnostic odds ratio; 95%-CI, 95% confidence interval; STTT, standard two-tier testing; MTTT, modified two-tier testing; Enz1, Enzygnost-1; Enz2, Enzygnost-2; Lia, Liaison; C6, C6-ELISA; RecomL, RecomLine; EM, erythema migrans; PopC, population control; CRC, cross-reactive control; strict, counting equivocal EIA results as negative; permissive, counting equivocal EIA results as positive