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. 2020 May 13;29(10):2651–2660. doi: 10.1007/s11136-020-02520-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Adjusted LS Mean Change from Baseline in QLQ-C30 GHS. Repeated measures mixed model with treatment by objective treatment response interaction, treatment by week interaction controlling for baseline QLQ-C30 GHS, comorbidity index, ECOG at baseline, age, AJCC stage, autoimmune comorbidity, therapy objective response to therapy. Positive number represents improvement in score, negative number represents deterioration. GHS/QoL global health quality of life scale, LS least squares, PEMBRO pembrolizumab, IPI + NIVO ipilimumab and nivolumab, CI confidence interval