Table 2.
Summary of population pharmacokinetic parameters
| Parameter description | Base model estimates (%RSE) | Final model estimates (%RSE) | Bootstrap estimate median (2.5–97.5%tiles) |
|---|---|---|---|
| Vmax (μg/day) | 2.75 (21.6%) | 1.70 (14.3%) | 1.82 (0.0901; 7.55) |
| KM (μg/mL) | 4.64 (42.5%) | 4.58 (15.1%) | 5.24 (0.533; 24.7) |
| Linear clearance, CL (L/day) | 0.331 (4.73%) | 0.331 (3.55%) | 0.327 (0.275; 0.364) |
| Influence of body weight on CL | – | 0.601 (19.5%) | 0.641 (0.355; 0.991) |
| Influence of albumin on CL | – | − 0.776 (19.9%) | − 0.777 (− 1.31; − 0.262) |
| Volume of central compartment, Vc (L) | 3.43 (2.76%) | 3.70 (2.98%) | 3.70 (3.51; 3.92) |
| Influence of body weight on Vc | – | 0.303 (24.8%) | 0.306 (0.109; 0.471) |
| Influence of sex on Vc | – | − 0.191 (23.4%) | − 0.194 (− 0.284; − 0.114) |
| Distribution clearance, Q (L/day) | 0.772 (10.6%) | 0.788 (8.99%) | 0.791 (0.599; 1.11) |
| Volume of peripheral compartment, Vp (L) | 2.07 (8.25%) | 2.05 (7.73%) | 2.08 (1.76; 2.42) |
| Interindividual variability of Vmax | 113 (32.6%) | 128 (23.3%) | 122 (65.9; 437) |
| Interindividual variability of CL | 36.0 (20.1%) | 27.1 (19.7%) | 25.5 (18.4; 31.7) |
| Interindividual variability of Vc | 22.2 (18.2%) | 17.3 (19.1%) | 16.8 (13.7; 19.9) |
| Interindividual variability of Vp | 59.3 (25.1%) | 60.0 (24.1%) | 56.0 (38.3; 74.9) |
| Covariance between CL and Vc | 0.0319 (36.2%) | 0.0141 (46.1%) | 0.0137 (0.00111; 0.0254) |
| Residual variability (%CV) | 14.4 (5.61%) | 14.5 (5.89%) | 14.4 (13.0; 15.7) |