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. 2020 Jul 10;237(11):3249–3257. doi: 10.1007/s00213-020-05607-8

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© The Author(s) 2020

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Fig. 1 — Acute alcohol does not induce locomotor stimulation in mice previously receiving 5-day sCT treatment when compared with the vehicle group. a Repeated sCT pre-administration (5 μg/kg, IP) for 5 days did not block locomotion caused by an acute alcohol injection (Alc, 1.75 g/kg, IP) administered on day 7 after sCT discontinuation. b Alcohol increased locomotion in mice at the time points of 5, 10, and 15 min after administration. After treatment discontinuation, sCT sustained an inhibitory effect on this alcohol-induced locomotion at the time point of 10 min after alcohol injection in the same behavioural setup. (Data are presented as mean ± SEM; *P < 0.05, ***P < 0.001 for Veh-Alc vs Veh-Veh, ^#P < 0.05 for sCT-Alc vs Veh-Alc comparisons; n.s., non-significant)